Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet

Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue. We investigated multigenerational study by focusing body weight, adipose tissue and plasma parameters male female mice. Pregnant C57BL6/J mice were exposed to (1.5 ?g/kg bw/day ie human equivalent dose 0.12 bw/day) drinking water from gestational day 0 post natal 21. All offsprings fed with high fat diet during 15 weeks. Body weight was monitored weekly mass measured before euthanasia. At euthanasia, blood glucose, insuline, triglyceride, cholesterol esterified fatty acid levels determined gene expressions visceral assessed. F1 males females mated obtain F2 generation. Likewise, cross-bred F3. The same analyses performed. In induced overweight associated lipolysis upregulation. females, dyslipidemia observed. F2, exposure increase VAT masses females. Several increased but sex related pattern (blood triglycerides NEFA females). observed down-regulation mRNA expression involved lipogenesis for only males. F3, decrease upregulation occurred sex-dependent effects, generation being most impacted. Transgenerational disturbances persisted